P/E2 Ratio Calculator

Progesterone-to-estradiol ratio with automatic unit conversion. For education only — not medical advice. Discuss your results with your clinician.

⚠️ Educational tool only. This calculator does not diagnose any condition and does not replace professional medical advice. There is no universally agreed P/E2 cutoff — reported values differ between studies.

Calculate P/E2 ratio

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Enter a valid progesterone value and a positive estradiol value.

Unit converter

Progesterone: —
Estradiol: —

What studies report (not recommendations)

ContextReported valueSource
IVF hCG trigger dayCutoff 0.30 (sens 40.0%, spec 72.4%, AUC 0.578)Reprod Biol Endocrinol 2021, PCOS cohort n=1254
IVF hCG trigger dayCutoff 0.58 (sens 69%, spec 55%, AUC 0.576, p=0.263)Prospective blastocyst ICSI cohort
IVF hCG trigger dayP/E2 > 0.55 with P > 1.5 ng/mL — no predictive value foundElgindy (blastocyst cycles)
Mid-luteal phase100–500 (both in pg/mL)Commonly reported range

AUC ≈ 0.58 means poor predictive value. Cutoffs vary across studies — there is no single agreed threshold.

Frequently asked questions

How is the P/E2 ratio calculated?

Convert both hormones to the same mass unit, then divide: P/E2 = progesterone (pg/mL) / estradiol (pg/mL). For example, progesterone 1.2 ng/mL equals 1200 pg/mL; divided by estradiol 2100 pg/mL gives a ratio of 0.5714.

How do I convert progesterone ng/mL to nmol/L?

Multiply ng/mL by 3.1801 to get nmol/L. For example, 1.2 ng/mL equals 3.8161 nmol/L. Divide nmol/L by 3.1801 to convert back.

How do I convert estradiol pg/mL to pmol/L?

Multiply pg/mL by 3.6713 to get pmol/L. For example, 2100 pg/mL equals 7709.73 pmol/L. Divide pmol/L by 3.6713 to convert back.

Is there a universal cutoff for the P/E2 ratio on IVF trigger day?

No. Studies report different cutoffs: 0.30 in a PCOS cohort of 1254 women (Reproductive Biology and Endocrinology, 2021) and 0.58 in a prospective blastocyst cohort, both with poor predictive value (AUC around 0.58). Cutoffs vary across studies, so discuss your result with your clinician.

What is a typical P/E2 ratio in the mid-luteal phase?

A range of 100 to 500 (both hormones in pg/mL) is commonly reported for cycling women tested in the mid-luteal phase. This is a reported range from the literature, not a diagnosis, and there is no single perfect number.

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